How Doses Compare: Mounjaro vs Ozempic

Here’s something that often surprises people: there’s no neat conversion between Mounjaro and Ozempic. They’re different molecules, so the doses don’t line up like swapping teaspoons for tablespoons.

That’s why prescribers usually start people back on the lowest Ozempic dose of 0.25 mg weekly, even if you were on a higher dose of Mounjaro. From there, they’ll gradually increase it, usually every four weeks or so. This slow build, called titration, helps balance effectiveness with tolerability.

It can feel frustrating, like you’re starting from scratch, but it’s not a setback. It’s about giving your body time to adapt and avoiding a wave of side effects hitting all at once.

Many users find they can stay on a lower dose for longer than the recommended titration timeline. Many UK prescribers will increase your dose monthly. But, a study earlier this year, revealed that those who stay on a lower dose, were more likely to stay on the treatment for longer and achieve the same results. You can read more about that in this article: Smaller Doses, Real Results: Why Going Up in GLP-1 Doses Isn’t Always Needed

What Side Effects to Expect if You Switch

Here’s the part nobody looks forward to: side effects can return when you switch. It’s a very common experience, and it doesn’t mean anything’s gone wrong.

If you remember those first few weeks on Mounjaro, the queasy mornings, the sudden mid-afternoon crash, the way your favourite meal suddenly lost its sparkle, don’t be surprised if some of that shows up again when you start Ozempic. For many people, it’s temporary. Your body just needs a few weeks to get used to a new rhythm.

Some users describe Ozempic as gentler, with fewer stomach issues. Others say the nausea hits harder than it did on Mounjaro. Both experiences are normal. The key is to give it time and to flag anything that feels extreme with your prescriber.

The Emotional Side: Frustration, Fear, and Relief

Switching isn’t only about molecules and doses. It’s about feelings, too.

There’s frustration at the price hikes, at having your treatment plan changed for reasons that have nothing to do with your progress. There’s fear of losing momentum, of watching the weight creep back, of wondering whether you’ll get the same results.

And then there’s relief. Relief when you realise your journey doesn’t end just because you change pens. Relief when your body starts to respond again and you see that this path is still working for you. Those emotions are all part of the process, and they’re worth acknowledging as much as the side effects.

Will I Get the Same Results on Ozempic as I Did on Mounjaro?

This is the question that usually lingers in the back of people’s minds. If Mounjaro felt like the magic bullet, will Ozempic measure up, or will you feel like you’ve gone backwards?

Here’s the honest answer: it depends. Both medications are effective, but they don’t work in exactly the same way. Mounjaro has that extra GIP pathway, and many users describe it as feeling more powerful in terms of appetite suppression. Some people do notice a difference when they switch.

But that doesn’t mean Ozempic won’t work for you. Plenty of people continue losing weight steadily on semaglutide, even after moving over from Mounjaro. In fact, for some, the change is barely noticeable once they reach their steady dose.

The key thing to remember is that results aren’t just about the medication; they’re about the combination of dose, time, side effect management, and the habits you’re building along the way. You may find that progress looks a little different, or moves at a slightly different pace. That doesn’t mean it’s not working.

So instead of comparing week by week, zoom out. If your prescriber is happy with your progress, your body is adjusting, and you feel able to sustain the treatment, then you are still moving in the right direction.

Real-World Experiences of Switching

Ask around and you’ll hear every version of this story. Some people say the transition was smoother than they expected, and within weeks, they barely noticed the difference. Others describe a bumpy start, with side effects creeping back before things levelled out. And then there are those who feel Mounjaro worked better for them.

The point is, experiences vary widely; it’s simply how bodies work. Your prescriber will guide the process so it fits your situation, not anyone else’s.

TL;DR

Switching from Mounjaro to Ozempic has become a very common experience in 2025, mainly driven by cost and availability. It’s considered safe when done under medical supervision, but the doses aren’t interchangeable, and most people will go through a re-titration phase.

Side effects often return in the early weeks, but they usually settle. The emotional side of the switch can feel just as real as the physical side with frustration, fear, and, for many, eventual relief.

And the most important part: many users do successfully switch and carry on their progress with Ozempic.

Friendly reminder: Everyone’s body responds differently, so always speak to your prescribing professional before making any changes.