What this means in practice
So, what can you actually expect in the first month? The honest answer is: it depends on who’s prescribing you and how cautious they are.
If you’re restarted at the lowest dose of Ozempic, the main hurdle isn’t usually side effects; it’s appetite control. Many people describe it as a temporary bump in the road, where food noise creeps back in and the urge to eat feels stronger than it did on Mounjaro. That can be unsettling, especially if you’d got used to feeling firmly “off switch.” But it’s also very common, and it usually improves as your dose steps up again.
If your clinic does attempt a dose-matching approach, you may skip that weaker appetite phase, but you could still run into side effects as your body adjusts to a different molecule. Even at “equivalent” doses, semaglutide doesn’t always feel the same as tirzepatide.
Either way, those first four weeks are best seen as a transition period. Not a time for dramatic results, but a time for adjustment. Most people report that things settle once their body finds its rhythm again, and prescribers will tweak doses if needed to get you back on track.
TL;DR
Switching from Mounjaro to Ozempic doesn’t come with a neat, official playbook. Different providers market different approaches, but in reality, most people end up starting at the lowest dose of semaglutide and titrating back up.
The one thing everyone agrees on? Leave seven days between your last Mounjaro injection and your first Ozempic one.
So, if you’re preparing for the switch, think of the first month as a transition phase. You may notice some side effects flickering back, or you might feel appetite control isn’t as strong at first. It’s often just a temporary bump in the road; progress may pause, but the bigger picture is about getting to the right dose and finding your rhythm again.
For the full guide on switching from Mounjaro to Ozempic, read this article: "Can I Switch to a Different GLP1? The Full Guide"
What providers are saying
A quick scan of private provider websites shows two main approaches being advertised:
Start low and titrate again: Most say you’ll restart on the lowest Wegovy dose (0.25 mg weekly), even if you were already on a higher Mounjaro dose. Then you’ll build up slowly, usually month by month, just like you did the first time. This is the cautious route, designed to limit side effects.
Match dose for dose: A handful claim they’ll transition you directly to an “equivalent” Ozempic dose, especially if you’ve tolerated Mounjaro well. This sounds appealing; there's no going backwards, no repeating the early slow climb. But here’s the kicker: we don’t actually know if that’s how it plays out once you’ve signed up.
Some of those bold promises could simply be marketing tactics to get clicks and sign-ups. Once you’re through the door, the prescribing team may well put you back on the lowest dose anyway.
What we do know for sure
One consistent point across all providers is the 7-day washout period. Whether you’re moving from Mounjaro to Ozempic or vice versa, the standard advice is to leave at least a week between your last jab and your first on the new drug. This avoids overlapping doses and keeps the transition safer.
If you’re on Mounjaro and thinking of moving to Ozempic, you’ve probably tried Googling what happens next. And if you did, you’ll know the answers are all over the place. Some clinics say you’ll go right back to the lowest dose. Others hint they’ll match your dose one-for-one. A few claim you’ll glide straight across with no bumps at all.
So which is true? Let’s unpack what’s really going on and what those first few weeks usually look like in the real world.
The missing piece: official guidance
First things first: there is currently no official dosing guidance from the MHRA or NICE on what happens when a patient switches from tirzepatide (Mounjaro) to semaglutide (Ozempic or Wegovy). That means prescribers don’t have a single, standardised playbook to follow. Instead, they draw on clinical judgement, trial data, and their own experience.
This explains why advice online looks so inconsistent.
Bite-Sized Podcasts
Listen to this article as audio
.png)
.png)
Nick M
Published:
4 Sept 2025
Updated:
6 Oct 2025
What Dose Will I Start on if I Switch from Mounjaro to Ozempic?
Starting Out
Helpful Companions For Your Weight Loss Journey
From meal ideas to daily tracking, these digital tools are designed to make life on GLP-1s a little easier.
.jpg)
.jpg)
.jpg)